Juan Carlos Aguillon Gutierrez

Bioquimico

Doctor en Bioquimica

Director Programa Disciplinario de Inmunologia

Profesor Titular

Línea de Investigacion

Patologia Autoinmune e Inflamatoria

jaguillo@med.uchile.cl

 

30. Carlos Gonzalez, Paula Abello, Raquel Cepeda, Lorena Salazar, Octavio Aravena, Bárbara Pesce, Diego Catalan, Juan Carlos Aguillon. Inflammation, synovial angiogenesis and chondroid apoptosis in the evolution of type II collagen-induced artritis. European Cytokine Network 2007; 18 (2).

29. Miguel Cuchacovich, Lilian Soto, Michael Edwardes, Miguel Gutierrez, Carolina Llanos, Daniel Pacheco, Francisca Sabugo, Mauricio Alamo, Carlos Fuentealba, Luciano Villanueva, Hector Gatica, Irene Schiattino, Lorena Salazar, Diego Catalan, Omar Valenzuela, Flavio Salazar-Onfray, Juan Carlos Aguillon. Tumour necrosis factor (TNF) -308 G/G promoter polymorphism and TNF levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology 2006; 35(6): 435- 440.

28. Carolina Figueroa, Alexis Peralta, Luisa Herrera, Pedro Castro, Andrea Gutierrez, Jorge Valenzuela, Juan Carlos Aguillon, Rodrigo Quera, Marcela A. Hermoso. NOD2/CARD15 and Toll-like 4 receptor gene polymorphism in Chilean patients with inflammatory bowel disease. European Cytokine Network 2006; 17(2): 125-130.

27. Juan Carlos Aguillon, Andrea Cruzat, Lorena Salazar, Carolina Llanos, Miguel Cuchacovich. Could single nucleotide polymorphisms (SNPs) affecting to the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution? Immunobiology 2006; 211(1-2): 75-84.

26. Mercedes Lopez, Carlos Ferrada, Elsa Cabrera, Raquel Aguilera, Claudio Perez, Ariadna Mendoza, Juan Carlos Aguillon, Flavio Salazar-Onfray. The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines. Immunobiology 2006; 211(1-2): 127-136.

25 John C. Mavropoulos, Miguel Cuchacovich, Carolina Llanos, Juan Carlos Aguillon, Hector Gatica, Salvatore V. Pizzo, Mario Gonzalez-Gronow. Anti- Tumor Necrosis Factor-α therapy augments Dipeptidyl Peptidase IV activity and decreases autoantibodies to GRP78/BIP and phosphoglucose isomerase in patients with rheumatoid arthritis. Journal of Rheumatology 2005; 32: 2116-2124.

24. Irene Schiattino, Rodrigo Villegas, Andrea Cruzat, Jimena Cuenca, Lorena Salazar, Octavio Aravena, Bárbara Pesce, Diego Catalan, Carolina Llanos, Miguel Cuchacovich, Juan Carlos Aguillon. Multiple imputation procedures allow the rescue of missing data: An application to determine serum tumor necrosis factor (TNF) concentration values during the treatment of rheumatoid arthritis patients with anti-TNF therapy. Biological Research 2005; 38: 7-12.

23. Claudio Perez, Fermín Gonzalez, Violeta Pavez, Veronica Araya, Adam Aguirre, Andrea Cruzat, Juan Contreras, Andres Dotte, Octavio Aravena, Lorena Salazar, Diego Catalan, Jimena Cuenca Arturo Ferreira, Irene Schiattino, Juan Carlos Aguillon. The –308 polymorphism in the promoter region of tumor necrosis factor-alpha (TNFα) gene and ex vivo lipopolysaccharide-induced TNFα expression in patients with aggressive periodontitis. European Cytokine Network 2004; 15 (4): 364-370.

22. Monica Kurte, Mercedes Lopez, Adam Aguirre, Alejandro Escobar, Juan Carlos Aguillon, Jehad Charo, Christian G. Larsen, Rolf Kiessling, Flavio Salazar-Onfray. A synthetic peptide homologous to the functional domain of human interleukin 10 downregulates the expression of the MHC class I alpha chain and TAP1/2 in human melanoma cells. Journal of Immunology 2004; 173: 1731-1737

21. Miguel Cuchacovich, Lorena Ferreira, Marta Aliste, Lilian Soto, Jimena Cuenca, Andrea Cruzat, Hector Gatica, Irene Schiattino, Claudio Perez, Adam Aguirre, Flavio Salazar-Onfray, Juan Carlos Aguillon. TNF-α levels and influence of –308 TNF-α promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis. Scandinavian Journal of Rheumatology 2004; 33: 228-232.

20. Maria Carmen Molina, Loreto Cruzat, Mauricio Canals, Pedro Cattan, Juan Carlos Aguillon, Arturo Ferreira. Development of immunometric assays to assess the alimentary behavior of Mepraia spinolai. Parasitology Research 2004; 92(5): 375-379.

19. A. Veronica Araya, Violeta Pavez, Claudio Perez, Fermin Gonzalez, Adam Aguirre, Alicia Colombo, Juan Carlos Aguillon. Ex vivo lipopolysaccharide (LPS)-induced TNFα, IL-1β, IL-6 and PGE2 secretion in whole blood from Type 1 diabetes mellitus patients with or without aggressive periodontitis. European Cytokine Network 2003; 14(3): 128-133.

18. Adam Aguirre, Alejandro Escobar, Viviana Ferreira, Maria C. Molina, Arturo Ferreira, Juan Carlos Aguillon. An anti-human recombinant tumor necrosis factor alpha (TNFα) monoclonal antibody recognizes an epitope in feline TNFα. Veterinary Research 2003; 34: 177-184.

17. Jimena Cuenca, Miguel Cuchacovich, Claudio Pérez, Lorena Ferreira, Adam Aguirre, Irene Schiattino, Lilian Soto, Andrea Cruzat, Flavio Salazar-Onfray, Juan Carlos Aguillon. The –308 polymorphism in the tumor necrosis factor gene promoter region and ex - vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in chilean patients with rheumatoid arthritis. Rheumatology (Oxford) 2003; 42: 308-313.

16. Jimena Cuenca, Claudio Perez, Adam Aguirre, Irene Schiattino, Juan Carlos Aguillon. Genetic polymorphism at position –308 in the promoter region of the tumor necrosis factor (TNF): Implications of its allelic distribution on susceptibility or resistance to diseases in the Chilean population. Biological Research 2001; 34: 237-241.

15. Juan Carlos Aguillon, Alejandro Escobar, Viviana Ferreira, Adam Aguirre, Lorena Ferreira, Maria Carmen Molina, Arturo Ferreira. Daily production of human tumor necrosis factor in LPS-stimulated ex vivo blood culture assays. European Cytokine Network  2001; 12: 105-110. 

14. Juan Carlos Aguillon, Lorena Ferreira, Claudio Pérez, Alicia Colombo, Maria Carmen Molina, Anne Wallace, Aldo Solari, Pilar Carvallo, Mario Galindo, Norbel Galanti, Anders Örn, Rosario Billetta, Arturo Ferreira. Tc45, a dimorphic Trypanosoma cruzi immunogen with variable chromosomal localization, is calreticulin. The American Journal of Tropical Medicine and Hygiene 2000; 63: 306-312.

13. Juan Carlos Aguillon, Tamara Hermosilla, Maria Carmen Molina, Antonio Morello, Yolanda Repetto, Anders Örn, Arturo Ferreira. Trypanosoma cruzi: H2 complex and genetic background influence on the humoral immune response against epimastigotes. International Journal for Parasitology 2000; 30: 981-984

12. Katherine Marcelain, Alicia Colombo, María Carmen Molina, Lorena Ferreira, Myriam Lorca, Juan Carlos Aguillon, Arturo Ferreira. Development of an immunoenzymatic  assay   for the detection  of   human antibodies against Trypanosoma cruzi calreticulin, an immunodominant antigen. Acta Tropica 2000; 75: 291-300.

11. Texia Gorman, Jimena Aballay, Fernando Fredes, Marco Silva, Juan Carlos Aguillon, Hector Alcaino. Immunodiagnosis of fasciolosis in horses and pigs using western blot. International Journal for Parasitology 1997; 27: 1429-1432. 

10. Juan Carlos Aguillon, Robert Harris, María Carmen Molina, Alicia Colombo, Claudio Cortes, Tamara Hermosilla, Paz Carreño, Anders Örn, Arturo Ferreira. Recognition of an immunogenetically  selected Trypanosoma cruzi antigen by  seropositive  chagasic human  sera. Acta Tropica 1997; 63: 159-166.  

9. Juan  Carlos  Aguillon, Viviana Ferreira, Eduardo Nuñez, Leonardo Paredes, Maria Carmen Molina, Alicia Colombo, Tamara Hermosilla, Arturo Ferreira. Immunomodulation of LPS ability to induce TNF in vivo and ex vivo assays.  Scandinavian Journal of Immunology 1996; 44: 551-555.

8. Rodrigo  Maass,  Livio  Zurita,  Carolina   Bustos,  Juan  Carlos  Aguillon, Arturo Ferreira. Radiolabeling of small peptides bound to a solid phase. Analytical Biochemistry 1995; 230: 343-345.

7. Juan Carlos Aguillon, Carolina Bustos, Patricia Vallejos, Tamara Hermosilla, Antonio Morello, Yolanda Repetto, Anders Örn, Ulf Hellman, Arturo Ferreira. Purification and preliminary sequencing of Tc45, an immunodominant Trypanosoma  cruzi  antigen:  Absence of  homology   with  cruzipain,  cruzain  and  a 46 kDa protein. The American Journal of Tropical Medicine and Hygiene 1995; 53: 211-215. 

6. Carolina  Bustos, Livio Zurita, Pedro Smith, Patricia Vallejos, Juan Carlos Aguillon, Arturo Ferreira. Humoral immune response anti-K99 pilus from enterotoxigenic Escherichia coli in experimentally inoculated calves. Biological Research 1995; 28: 277-282. 

5. Michael Seeger, Cecilia Sepúlveda, Patricia Vallejos, Juan Carlos Aguillon, Arturo Ferreira. A simple method for negative and positive selection of murine and human IgM-bearing lymphocites. Journal of Immunological Methods 1993; 162: 109-114.  

4. Juan  Carlos  Aguillon,  Rodrigo  Ramos,  Mario Chiong, Patricia Vallejos, Arturo Ferreira. Soybean proteins: Alternative blocking agents for immunoassays using nitrocellulose or plastic solid phases. Biological Research 1992; 25: 79-83. 

3. Mario Chiong, Sergio Lavandero, Rodrigo Ramos, Juan Carlos Aguillon, Arturo Ferreira. Silica octadecil: A solid phase for immunoaffinity protein purifications.  Analytical Biochemistry 1991; 197: 47-51. 

2. Rodrigo Ramos, Maritza Juri, Alicia Ramos, Gustavo Hoecker, Sergio Lavandero, Pedro Peña, Antonio Morello, Yolanda Repetto, Juan Carlos Aguillon, Arturo Ferreira. An immunogenetically defined and immunodominant Trypanosoma cruzi antigen. The American Journal of Tropical Medicine and Hygiene 1991; 44: 314-322.

1. Leandro Herrera, Paulina Ruiz, Juan Carlos Aguillon, Alexis Ferhmann. A new spectrophotometric method for the determination of ferrous iron in the presence of ferric iron. Journal of Chemistry Technology and Biotechnology 1989; 44: 171-181.

 

 

Arturo Ferreira Vigouroux

Medico Veterinario

Doctor en Ciencias

Sub-Director de Investigación ICBM

Profesor Titular

Programa Disciplinario de Inmunologia

Departamento de Bioquimica y Biologia Molecular

Facultad de Ciencias Quimicas y Farmaceuticas

Linea de Investigacion

Inmunologia de la Agresion Microbiana

aferreir@med.uchile.cl

Proyectos Adjudicados

Investigador Principal o Director . (19 en total. Aproximadamente US$ 3.725.000)

Proyectos Bicentenario de Anillos de Investigacion . Enfermedad de Chagas: Control de la Infectividad de Trypanosoma cruzi por Productos de Origen Natural, Sintetico e Inmunologico 2005-2007. $450.000.000.

ICGEB . Targeting by genetic (DNA) immunization of the survivin inhibitor of apoptosis, a generic tumor associated antigen. 2003-2005. US$ 60.000.

MECESUP UCH 0115. Proyecto de Red Nacional de Postgrado . Tercer Concurso Fondo Competitivo. Red Nacional de Programas de Doctorado en Biociencias Moleculares: Una Articulacin Multidisciplinaria, Interregional, Horizontal y Dinamica. (Universidad de Chile, Pontificia Universidad Catlica, de Chile, Universidad Austral de Chile, Universidad de Concepcion, Centro de Estudios Cientificos). 2002-2004. US$ 1.806.260.

FONDECYT Rol de Calreticulina de Trypanosoma cruzi en la Modulacion de Interacciones Huesped /Parasito. 2001-2004. US$ 152.857.

INSERM/CONICYT . Mecanismos de Accion de Inmunoglobulinas Endovenosos en Enfermedades Autoinmunes. 1998-2000. US$ 20.000.

RELACIN/UNESCO . Red Latinoamericana de Centros de Inmunologia. 1996-1997. US$ 55.000.

FONDECYT: Deteccion, Caracterizacion y Produccion de Antigenos de Trypanosoma cruzi : El Modelo de Tc45, un Nuevo Inmunogeno. 1997-1999. US$ 150.000.

FONDEF : Promocion de Transferencia Inmunobiotecnologica. 1996-1997. US$ 60.000.

FONDECYT. "Deteccion Caracterizacion y produccion de Antigenos de Trypanosoma cruzi , Inmunogeneticamente Definidos. 1994 - 1996. US$ 120.000.

FONDEF. "Centro de Referencia para la Produccion de Reactivos Inmunologicos, Expansion in vitro de Anticuerpos Monoclonales y Desarrollo de Metodologia Inmunologica Relevante". 1994 - 1997. US$ 300.000.

FONDECYT. Deteccion y Caracterizacion Molecular de Algunos Antgenos Trypanosoma cruzi ; Potencial en el Diagnostico/Pronostico de la Enfermedad de Chagas. 1990-1993. US$ 50.000.

Swedish Agency for Research Cooperation with Developing Countries (SAREC). "Molecular aspects of immunogenetic resistance to Trypanosoma cruzi ".1990-1997. US$ 300.000.

PNUD . Programa Regional de Biotecnologa. Programa de las Naciones Unidas Para el Desarrollo. Grant de Entrenamiento. 1991-1993. U.S.$43.000.

Universidad de Chile. Direccion General Academica y Estudiantil . Departamento Tecnico de Investigacion. "Desarrollo de Metodologia Inmunoquimica para el Diagnostico de la Enfermedad de Chagas y de la Tuberculosis ". 1988-1990. US$ 1.500

UNPD/WORLD BANK/WHO . Special Programme for Research and Training in Tropical Diseases. "Development and standardization of a non-conventional immunologic approach for the Diagnosis of Chagas' Disease". 1990-1991. U.S.$57.000

FONDECYT . "Desarrollo e Imple�mentacion de Tecnologia Inmunoquimica Moderna para la Deteccion de Moleculas de Importancia Biomedica. Aplicacion al Diagnostico de la Enfermedad de Chagas y de la Tuberculosis ". Junio 1988-Mayo 1991. US $ 53.177.

UNDP/WORLD BANK/WHO . Special Programme for Research and Training in Tropical Diseases (TDR). "Clinical and Basic Biology of Chagas' Disease". Institutional strengthening Grant. 1986-1988. US $ 18.000.

FONDECYT . "Identificacion y caracterizacion de antigenos de Trypanosoma cruzi con capacidad inmunogenica protectora en cepas de ratones resistentes y sensibles a la enfermedad de Chagas". Agosto 1987-Julio 1988. US $ 10.000.

National Institute of Health . "Immunospecific regions of the protective antigens of Plasmodium knowlesi ". Febrero 1985 � Febrero 1989. US $ 200.000.

Agency for International Deve­lopment . "The use of specific DNA probes to detect and quantitative malaria exoerythocytic forms". Marzo 1985 � Febrero 1989. US $ 280.000

•  Co-Investigador : En 9 Proyectos. (8 FONDECYT, 2 FONDEF)

 

Manuscritos enviados

104.- Osvaldo Garrido, Rene Letelier, Marcela Fuenzalida, Anibal Guerrero, Luis Sarabia, Inge Maurer, Arturo Ferreira , David. Lemus. Tumor angiogenesis in mouse organs with metastasis: 'proliferative index' after betamethasone treatment. 2006. Enviada.

103.- Carolina Ribeiro, Viviana Fererira, Rosario Billetta, Wilhelm Schwaeble, Mara Carmen Molina, Arturo Ferreira . 2006. Immunization with Trypanosoma cruzi calreticulin and its coding DNA increases parasitemia in mice. Enviada.

 

Manuscritos Publicados

102.- Miguel Mejias, Maria Carmen Molina, Arturo Ferreira . 2005. Ruptura de la Barrera Hematoencefalica Determinada en Ensayos Inmunometricos de Liquido Cefalorraquideo. En prensa.

101.- A. Goecke, C. Alvarez, J. Henriquez, K. Salas, M.L. Molina, Arturo Ferreira, H. Gatica. Methotrexate regulates the expresin of glucocorticoid receptor alpha and beta isoforms in normal human monocytes and human limphocyte cell lines in vitro . 2007. Molec. Immunono l. 44 : 2115-2123

100.- M N. Lopez, C. Pereda, M. Ramirez, A. Mendoza-Naranjo, A. Serrano, Arturo Ferreira , R. Poblete, A.M. Kalergis, R. Kiessling, and F. Salazar-Onfray. Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy. Invest. Oph. Vis. Sc i. 2007. 48 : 1219-1227.

99.- JD Maya, BK Cassels, P Iturriaga-Vasquez, J Ferreira, M Faundez, N Galanti, Arturo Ferreira , A Morello. (2006). Mode of action of Natural and Synthetic Drugs Against Trypanosoma cruzi and their Interaction with the Mammalian Host. Comp. Biochem Physiol. A Mol. Integr. Physiol . Marzo 2006 . 601-620

98.- Algunos mecanismos inmunes implicados en el dolor ; En : INMUNOLOGIA BASICA Y CLINICA . Arturo Ferreira , C. Sepulveda. Eds. Editorial Mediterraneo. Santiago- Chile. 2005. 669-675.

97.- A Lladser, M Parraga, L Quevedo, M C Molina, S Silva, Arturo Ferreira , R Billetta, A Quest. (2006). Naked DNA Immunization as an approach to Target the Generic Tumor Antigen Survivin Induces Humoral and Cellular Immune Response in Mice. Immunobiology. 211: 11-27 .

96.- L Aguilar, G Ramirez, C Valck, M C Molina, A Rojas, W Schwaeble , V Ferreira, Arturo Ferreira . (2005). F(ab') 2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first complement component. Biological Research. 38: 187-195.

95.- C Perez, V Pavez, V Araya, F Gonzalez, A Aguirre, A Cruzat, J Cuenca, J Contreras, A Dotte, Arturo Ferreira , I Schiattino, J C. Aguillon. (2004). The -308 polymorphism in the promoter region of tumor necrosis factor-alpha (TNF α ) gene and ex vivo lipopolysaccharide-induced TNF α expression in patients with aggressive periodontitis. European Cytokine Network . 15: 364-370.

94.- V Ferreira, M C Molina, W. Schwaeble, D. Lemus and Arturo Ferreira . 2005. Trypanosoma cruzi Calreticulin in the Parasite / Host Relationship: Modulation of the Complement System and Angiogenesis. Trends in Parasitology . 21: 169- 174..

93.- M C Molina, V Ferreira, C Valck, G Ramirez, L Aguilar, A Rojas, R Billetta, D Lemus, Arturo Ferreira . 2005. An in vivo role for Trypanosoma cruzi calreticulin in antiangiogenesis. Molecular and Biochemical Parasitology. 140: 133-140.

92.- Juan Carlos Aguillon y Arturo Ferreira . Preguntas. En: INMUNOLOGIA BASICA Y CLINICA. A. Ferreira, C. Sepulveda, A. Afani, J. C. Aguillon, P. Lanza. Eds. Editorial Mediterraneo. Santiago- Chile. 2005. 381-403

91.- Omar Barriga y Arturo Ferreira. Respuesta Inmune Contra Agresores Intra y Extracelulares: Parasitos. En: INMUNOLOGIA BASICA Y CLINICA. A. Ferreira, C. Sepulveda, A. Afani, J. C. Aguillon, P. Lanza. Eds. Editorial Mediterraneo. Santiago- Chile. 2005. 194-209.

90.- Arturo Ferreira y Viviana Ferreira . El Sistema del Complemento En: INMUNOLOGIA BASICA Y CLINICA. A. Ferreira, C. Sepulveda, A. Afani, J. C. Aguillon, P. Lanza. Eds. Editorial Mediterraneo. Santiago- Chile. 2005. 130-150.

89.- Arturo Ferreira. Procesamiento Antigenico y Presentacion de Linfocitos. Parte A: Antigeno. En: INMUNOLOGIA BASICA Y CLINICA. A. Ferreira, C. Sepulveda, A. Afani, J. C. Aguillon, P. Lanza. Eds. Editorial Mediterraneo. Santiago- Chile. 2005. 79-85

88.- Arturo Ferreira. Introduccion al Sistema Inmune. En: INMUNOLOGIA BASICA Y CLINICA. A. Ferreira, C. Sepulveda, A. Afani, J. C. Aguillon, P. Lanza. Eds. Editorial Mediterraneo. Santiago- Chile. 2005. 3-9

87.- M. Carmen Molina, Loreto Cruzat, Mauricio Canals, Pedro Cattan, Juan Carlos Aguillon, Arturo Ferreira. 2004. Development of Immunometric Assays to Asses the Alimentary Behavior of Mepraia spinolai . Parasitology Research. 92: 375-379.

86.- V.Ferreira, C. Valck, G. Sanchez, A. Gingras, S. Tzima, M.C. Molina, R. Sim, W. Schwaeble, Arturo Ferreira . 2004. The Classical Activation Pathway of the Human Complement System is Specificaly Inhibited by Calreticulin from Trypanosoma cruzi. Journal of Immunology . 172: 3042-3050.

85.- Ferreira, V., Molina, M.C., Valck, C., Rojas, A., Aguilar, L., Ramirez, G., Schwaeble, W. and Ferreira, Arturo . 2004. Role of Calreticulin from Parasites in its Interaction with Vertebrate Hosts. (revisin por invitacin). Molecular Immunology. 40: 1279-1291.

84.- Adam Aguirre, Alejandro Escobar, Viviana Ferreira, Maria Carmen Molina, Arturo Ferreira , Juan Carlos Aguillon. 2003. An Anti-Human Recombinant Tumor Necrosis Factor Alpha (TNF alpha ) Monoclonal Antibody Recognizes an Epitope in Feline TNF alpha . Veterinary Research. 34: 177-184.

83.- Arturo Ferreira y Julio Scharfstein. El Sistema del Complemento. En: FUNDAMENTOS DE INMUNOLOGIA BASICA Y CLINICA. I. Palomo, A. Ferreira, C. Sepulveda, M Rosemblatt, U. Vergara, Eds. Editorial Universidad de Talca, Talca, Chile. 2002. Pgs. 327-348.

82.- Ivan Palomo y Arturo Ferreira . La Historia de la Inmunologia. En : FUNDAMENTOS DE INMUNOLOGIA BASICA Y CLINICA. I. Palomo, A. Ferreira, C. Sepluveda, M Rosemblatt, U. Vergara, Eds. Editorial Universidad de Talca, Talca, Chile. 2002. Pgs. 45- 52.

81.- Veronica Araya, Adam Aguirre, Carmen Romero, Maria Carmen Molina, Cristian Miranda, Arturo Ferreira . 2002. In vitro TNF Alpha Producing Capacity of Lipopolysaccharide Stimulated Monocytes from Women with Polycystic Ovary Syndrome. European Cytokine Network . 13: (4) 1-6.

80.- Viviana Ferreira, Maria Carmen Molina, Carolina Valck, Alvaro Rojas, Arturo Ferreira . 2002. Parasite Calreticulin: Possible Roles in the Parasite / Host Interface. Inmunologa (Madrid) . 21: (3) 156 –168.

79.- Mauricio Canals, Loreto Cruzat, Maria Carmen Molina, Arturo Ferreira , Pedro Cattan. 2001. Blood Host Sources of Mepraia spinolai ( Hemiptera, Reduviidae ), wild Vector of Chagas Disease in Chile . Journal of Medical Entomology . 38: 303-307.

78.- Juan Carlos Aguillon, Lorena Ferreira, Viviana Ferreira, Alejandro Escobar, Adam Aguirre, Maria Carmen Molina and Arturo Ferreira . 2001. Assessment of Inter-Individual Variations in the Daily Production of Human Tumor Necrosis Factor an ex vivo Blood Culture Assay. European Cytokyne Network . 12: 105-110.

77.- Juan Carlos Aguillon, Maria Carmen Molina, Tamara Hermosilla, Antonio Morello, Yolanda Repetto, Anders rn and Arturo Ferreira . 2000. Trypanosoma cruzi : H2 Complex and Genetic Background Influence in the Humoral Immune Response Against Epimastigotes. International Journal Parasitology. 30 : 981-984.

76.- Juan Carlos Aguillon, Lorena Ferreira, Claudio Perez, Heriberto Arevalo, Alicia Colombo, Maria Carmen Molina, Aldo Solari, Anne Wallace, Norbel Galanti, Mario Galindo, Pilar Carvallo, Anders rn, Rosario Billetta and Arturo Ferreira . 2000. Tc45, a Dimorphic Trypanosoma cruzi Immunogen, is Calreticulin. American Journal of Tropical Medicine and Hygiene . 63: 306-312 .

75.- Katherine Marcelain, Alicia Colombo, Maria Carmen Molina, Juan Carlos Aguillon and Arturo Ferreira. 2000. Development of an Immunoenzymatic Assay for the Detection of Human Antibodies Against Trypanosoma cruzi antigen Calreticulin, an Immunodominant Antigen. Acta Tropica, 75: 291-300.

74.- Arturo Ferreira , Lorena Ferreira, Juan Carlos Aguillon. 1998. Deteccion de Colonias Bacterianas Recombinantes para Antigenos Parasitarios Mediante Inmunosondas Radiometrica o Enzimaticas. En TECNOLOGIAS APLICADAS AL DIAGNOSTICO E INVESTIGACION DE ENFERMEDADES PARASITARIAS (A. Ferreira, N. Galanti, M. Lorca, A. Morello, A. Solari y U. Vergara, eds.) Network for Research and Training in Parasitic in Parasitic Diseases in the Sourthern Cone of Latin America . SIDA/SAREC Sweden.

73.- Ivan Palomo y Arturo Ferreira . Historia de la Inmunologia. En : FUNDAMENTOS DE INMUNOLOGIA. I. Palomo, A. Ferreira, C. Sepulveda, M. Rosemblatt and U. Vergara, Eds. Editorial Universidad de Talca, Talca, Chile. 1998. Pags. 319-349.

72.- Arturo Ferreira . El Sistema del Complemento. En: FUNDAMENTOS DE INMUNOLOGIA. I. Palomo, A. Ferreira, C. Sepulveda, M. Rosemblatt and U. Vergara, Eds. Editorial Universidad de Talca, Talca, Chile. 1998. Pags. 35-41.

71.- Arturo Ferreira . 1997. Inmunidad anti Protozoaria. Destilado de Hechos Recientes. Parasitologia al Da . Vol. 2. Pags. 79-82. (Por invitacin).

70.- Juan Carlos Aguillon, Pedro Smith, Alicia Colombo, Maria Carmen Molina y Arturo Ferreira . 1997. Anticuerpos Policlonales Anti-Immunoglobulinas de Salmon Herramientas Potenciales para Diagnostico. Archivos de Medicina Veterinaria . 29 (1): 133-139.

69.- Claudio Cortes, Livio Zurita, Patricia Vallejos, Carolina Bustos, Maria Carmen Molina, Juan Carlos Aguillon and Arturo Ferreira . 1997. Generacion y Evaluacion de un Anticuerpo Monoclonal anti-pili K99 de Escherichia coli enteropatogena. A rchivos de Medicina Veterinaria . 63: 159-166.

68.- Juan Carlos Aguillon, Maria Carmen Molina, Alicia Colombo, Claudio Cortes, Tamara Hermosilla, Paz Carreo, Anders rn and Arturo Ferreira . 1997. Recognition of an Immunogenetically Selected T. cruzi Antigen by Seropositive Chagasic Human Sera. Acta Tropica . 63: 159-166.

67.- Juan Carlos Aguillon, Viviana Ferreira, Eduardo Nez, Leonardo Paredes, Maria Carmen Molina, Alicia Colombo, Tamara Hermosilla and Arturo Ferreira . 1996. Immunomodulation of LPS Ability to Induce TNF In vivo and Ex vivo Assays. Scandinavian of Journal Immunology. 44: 551-555 .

66.- Texia Gorman, Alicia Valdes, Fernando Fredes, Arturo Ferreira and Hector Alcaino. 1995. Reconocimiento Antigenico de Ovinos Naturalmente Infectados con Fasciola hepatica . Monitoreo a traves de Inmunoelectrotransferencia Enzimatica (Western Blotting). Archivos de Medicina Veterinaria . 27: 33-40 .

65.- Carolina Bustos, Livio Zurita, Pedro Smith, Patricia Vallejos, Rodrigo Ramos, Juan Carlos Aguillon and Arturo Ferreira . 1995. Humoral Immune Response Anti K99 Pilus from Enterotoxigenic Escherichia coli in Experimentally Inoculated Calves. Biological Research . 28 : 277-282

64.- Rodrigo Maass, Livio Zurita, Carolina Bustos, Juan Carlos Aguillon and Arturo Ferreira . 1995. Radiolabeling of Small Peptides Bound to a Solid Phase. Analytical Biochemistry . 230: 343-345.

63.- Juan Carlos Aguillon, Carolina Bustos, Patricia Vallejos, Tamara Hermosilla, Antonio Morello, Yolanda Repetto, Ulf Hellman, Anders rn and Arturo Ferreira . 1995. Purification and Preliminary Sequencing of Tc45, an Immunodominant Trypanosoma cruzi Antigen: Absence of Homology with Cruzipain, Cruzain, and a 46-Kilodalton Protein. T he American Journal of Tropical Medicine and Hygiene . 52: 211-215.

62.- Texia Gorman, Vania Concha, Fernando Fredes, Arturo Ferreira , Alicia Valdes, Hector Alcaino. 1994. Deteccion de antigenos de interes diagnostico en infecciones animales por Fasciola hepatica. Parasitologa al Dia 18: 26-32.

61.- Pedro Smith, Livio Zurita, Francisco Canale, Arturo Ferreira , Haroldo Toro. 1994. K99 Pili of Escherichia coli on solid phase for ELISA antibody determinations in calves. Veterinary Microbiology. 40: 387-392

60.- Juan Carlos Aguillon, Myriam Lorca, Patricia Vallejos, Arturo Ferreira . 1994. Evaluacion inmunoradiometrica de orina humana y murina como especimenes para la deteccion de antigenos de Trypanosoma cruzi . Parasitologia al Dia . 18: 4-8.

59.- Juan Carlos Aguillon, Patricia Vallejos, Anders rn, Roland Andersson, Arturo Ferreira . 1993. Restriccion inmunogenetica en la respuesta a antigenos de Trypanosoma cruzi . Acta Andina 2 (1): 135-136.

58.- Michael Seeger, Cecilia Sepulveda, Patricia Vallejos, Juan Carlos Aguillon, Arturo Ferreira . 1993. A simple method for negative and positive selection of murine and human IgM-bearing lymphocytes. Journal of Immunological Methods . 162: 109-114

57.- Haroldo Toro, Pablo Lavaud, Patricia Vallejos, Arturo Ferreira . 1993. Transfer of IgG from serum to lachrymal fluid in chickens. Avian Diseases 37: 60-66 .

56.- Texia Gorman, Vania Concha, Hector Alcano, Fernando Fredes, Hugo Gonzalez, Arturo Ferreira . 1992. Caracterizacion de antigenos de Fasciola hepatica mediante inmunoprecipitacion en agarosa. Parasitologia al Dia . 16: 81-86. (Por invitacion)

55.- Juan Carlos Aguillon, Mario Chiong, Rodrigo Ramos, Patricia Vallejos, Arturo Ferreira . 1992. Soybean proteins: Alternative blocking agents for immunoassays using nitrocellulose or plastic solid phases. Biological Research . 25: 79-83.

54.- Arturo Ferreira . 1992. Biotecnologia: Las ciencias biologicas al servicio de la generacion de productos destinados a mejorar la calidad de vida del hombre. Monografias de Medicina Veterinaria. 14 : 3-9 (por invitacion).

53.- Juan Carlos Aguillon, Rodrigo Ramos, Alejandro Chabalgoity, Alberto Nieto, Antonio Morello, Yolanda Repetto, Arturo Ferreira . 1991. Tc45, un antgeno inmunogenticamente definido de Trypanosoma cruzi : Estrategias cromatogrficas para su purificacin. Parasitologa al Da . 15: 79-86.

52.- Sergio Lavandero, Juan F. Santibaez, Mara Paz Ocaranza, Arturo Ferreira , Mario Sapag-Hagar. 1991. Binding and production of insulin like growth factor I in rat mammary tissue. Comparative Biochemistry and Physiology . A99: 507-511.

51.- Rodrigo Ramos, Maria Juri, Alicia Ramos, Gustavo Hoecker, Sergio Lavandero, Pedro Pea, Antonio Morello, Yolanda Repetto, Juan Carlos Aguillon, Arturo Ferreira . 1991. An immunogenetically defined and immunodominant Trypanosoma cruzi antigen. American Journal of Tropical Medicine and Hygiene 44: 314-322.

50.- Mario Chiong, Sergio Lavandero, Rodrigo Ramos, Juan Carlos Aguillon, Arturo Ferreira . 1991. Octadecyl silica: A solid p hase for protein purification by immunoadsorption. Analytical Biochemistry 197 : 47-51.

49.- Maria A. Juri, Arturo Ferreira , Alicia Ramos, Gustavo Hoecker. 1990. Nonlytic antibodies in H2 controlled resistance to acute infection with Trypanosoma cruzi . Brazilian Journal Medicine and Biological Research 23: 685-695.

48.- Arturo Ferreira , Sergio Lavandero. 1988. A non-conventional solid phase for immunoradiometric assays of potential use in the diagnosis of Chagas' disease. M emorias do Instituto Oswaldo Cruz 83: 466-470.

47.- Arturo Ferreira . 1988. Factor de necrosis tumoral humano: Efecto contra un parsito intracelular. Anales de la Universidad de Chile 14: 170-186 (por invitacin)

46.- Sergio Lavandero, Arturo Ferreira . 1988. Use of octadecyl silica as a non-conventi/onal solid phase in immunoradiometric assays. Journal of Immunological Methods . 114 : 261-265.

45.- Louis, Schofield, Arturo Ferreira . 1988. Interferon, immunity and intracellular pathogens: Antimalarial effect of gamma interferon. In : Interferon Immunity and Intracellular Pathogens. Jeniffer Turco (Ed.). Elsevier Publications. Cambridge U.K. pp 217-233.

44.- Arturo Ferreira , Louis Schofield. 1988. Evaluacion de la actividad anti-parasitos intracelulares de anticuerpos, interferon y celulas inmunocompetentes. Avances en Ciencias Veterinarias 3: 12-20.

43.- Louis Schofield, Arturo Ferreira , Victor Nussenzweig and Ruth Nussenzweig. 1987. Anti-Malarial Activity of Alpha Tumor Factor and Gamma-Interferon. Federation Proceedings . 46: 760.

42.- Louis Schofield, Jaime Villaquiran, Arturo Ferreira , Huub Chellekens, Ruth Nussenzweig, Victor Nussenz­weig. 1987. Gamma-interferon, CD8 + T cells and antibodies required for immunity to malaria sporozoites. Nature 330: 664-666.

41.- Louis Schofield, Arturo Ferreira , Rita Altszuler, Victor Nussenzweig, Ruth Nussenzweig. 1987. gamma-interferon inhibits the intrahepatocytic development of malaria parasites in vitro . Journal of Immunology 139: 2020-2025 .

40.- Ulises Vergara, Arturo Ferreira , Huub Shellekens, Victor Nussenzweig. 1987. Mechanism of escape of exoerythrocytic forms (EEF) of malaria parasites from the inhibitory effects of gamma interferon. Journal of Immunology 138: 4447-4449.

39.- Arturo Ferreira , Takashi Morimoto, Rita Altszuler, Victor Nussenzweig. 1987. Use of a DNA probe to measure the neutralization of Plasmodium berghei sporozoites by a monoclonal antibody. Journal of Immunology 138: 1256-1259 .

38.- Arturo Ferreira , Louis Schofield, Vincenzo Enea, Huub Schellekens, Peter van der Meide, William E. Collins, Ruth Nussenzweig, Victor Nussenzweig. 1986. Inhibition of development of exoerythrocytic forms of malaria parasites by γ interferon. Science 232: 881-884 .

37.- Arturo Ferreira , Vincenzo Enea, Takashi Morimoto, Victor Nussenzweig. 1986. Infectivity of Plasmodium berghei sporozoites measured with a DNA probe. Molecular and Biochemical Parasitology 19: 103-109.

36.- Diane M. Robins, Marie Malissen, Leroy Hood, Arturo Ferreira , Deborah Walthall, Mark Mitchell. 1986. Multiple C4/Slp genes distinguished by expression following transfection. Molecular and Cellular Biology . 6: 134-141.

35.- Santiago Rodriguez de Cordoba, Arturo Ferreira , Pablo Rubinstein. 1985. Does the mouse C4-binding protein gene ( C4-bp ) map in the H2 region? Immunogenetics 21: 257-265.

34.- Ulises Vergara, Andres Ruiz, Arturo Ferreira , Ruth S. Nussenzweig, Victor Nussenzweig. 1985. Conserved group-specific epitopes of the circumsporozoite proteins revealed by antibodies to synthetic peptides. Journal of Immunology 134: 3445-3448.

33.- Ulises Vergara, Robert Gwadz, David Schlesinger, Victor Nussenzweig, Arturo Ferreira . 1985. Multiple non-repeated epitopes on the circumsporozoite protein of Plasmodium knowlesi . Molecular and Biochemical Parasitology 14: 283-292.

32.- Santiago Rodriguez de Cordoba, Pablo Rubinstein, Arturo Ferreira . 1984. High resolution isoelectric focusing of immunoprecipitated proteins under denaturing conditions. A simple analytical method applied to the study of complement component polymorphisms. Journal of Immunological Methods 69: 165-172.

31.- Arturo Ferreira . 1984. El complejo mayor de histocompatibilidad del ratn y el sistema del complemento: Inmunologa (Madrid) 3 : 89-97.

30.- Arturo Ferreira , Victor Nussenzweig. 1983. Murine sex-limited protein (Slp) antigenic sites in human complement component C4. Immunogenetics 18: 335-341.

29.- Santiago Rodriguez de Cordoba, Arturo Ferreira , Victor Nussenzweig, Pablo Rubinstein. 1983. Genetic polymorphism of human C4-binding protein (C4-bp). Journal of Immunology 131: 1565-1569.

28.- Ferrucio Santoro, Alan Cochrane, Elizabeth Nardin, Victor Nussenzweig, Ruth Nussenzweig, Arturo Ferreira . 1983. Structural similarities among the protective antigens of sporozoites from different species of malaria parasites. The Journal of Biological Chemistry 258 : 3341-3345.

27.- Arturo Ferreira , Daniel Eichinger, Victor Nussenzweig. 1982. The H2 controlled sex-limited protein (Slp): reassessment of its sex limitation. Journal of Immunology 129: 1506-1508.

26.- Arturo Ferreira . 1981. Variaciones funcionales en genes H2 duplicados. Archivo de Biologa y Medicina Experimentales (actualmente, Biological Research ). 14: 31-32.

25.- Arturo Ferreira , Daniel Eichinger. 1981. A simplified two-dimensional electrophoretic technique. Journal of Immunological Methods 43: 291-299 .

24. - James Michaelson, Arturo Ferreira , Victor Nussenzweig. 1981. Cis interacting genes in the S region of the major histocompatibility complex of the mouse. Nature 289: 306-308.

23. - Arturo Ferreira , James Michaelson, Victor Nussenzweig. 1980. Polymorphism of the gamma chains of murine Ss and Slp proteins. Immunobiology 158: 3-4

22.- Arturo Ferreira , James Michaelson, Victor Nussenzweig. 1980. H2 controlled polymorphism of the gamma chain of Slp (sex-limited protein). Immunogenetics 11: 491-497.

21.- Arturo Ferreira , Chella David, Victor Nussenzweig. 1980. The murine H-2.7 specificity is an antigenic determinant of C4d, a fragment of the fourth component of the complement system. Journal of Experimental Medicine 151: 1424-1435 .

20.- Arturo Ferreira , James Michaelson, Victor Nussenzweig. 1980. A polymorphism of the gamma chain of mouse C4 controlled by the S region of the mouse major histocompatibility complex. Journal of Immunology 125: 1178-1182.

19.- Arturo Ferreira , Victor Nussenzweig. 1979. Mouse C4 (Ss): Three-step purification of its C4c fragment and production of a monospecific antiserum. Journal of Immunology 122: 490-493.

18.- Arturo Ferreira , Victor Nussenzweig, Irma Gigli. 1978. Structural and functional differences between of the H2 controlled Ss and Slp proteins. Journal of Experimental Medicine 148: 1186-1197.

17.- Arturo Ferreira , Paul Weisz-Carrington, Victor Nussenzweig. 1978. Testosterone control of serum levels of C4-binding protein in mice. Journal of Immunology 121: 1213-1215 .

16.- Julio Scharfstein, Arturo Ferreira , Irma Gigli, Victor Nussenzweig. 1978. Presence of a C4-binding protein in human serum. Journal of Immunology 120: 1795.

15.- Arturo Ferreira , Paul Weisz-Carrington, Irma Gigli, Victor Nussenzweig. 1978. Purification and characteri­zation of a mouse serum protein with specific binding affinity for C4 (Ss protein). II. Journal of Immunology 120: 1772-1773.

14.- Julio Scharfstein, Arturo Ferreira , Irma Gigli, Victor Nussenzweig. 1978. Human C4-binding protein. Isolation and characterization. Journal of Experimental Medicine 148 : 207-222.

13.- Arturo Ferreira , Morinobu Takahashi, Victor Nussenz­weig. 1977. Purification and characterization of a mouse serum protein with specific binding affinity for C4 (Ss). I. Journal of Experimental Medicine 146: 1001-1018

12.- Arturo Ferreira , Marilena Fotino, Victor Nussenzweig. 1976. The relationship between 4a (w4) and 4b (w6) HLA de�termined specificites and the receptors for C3 on the membrane of leukocytes. European Journal of Immunology 6: 832-833

11.- Morinobu Takahashi, Joyce Czop, Arturo Ferreira , Victor Nussenzweig. 1976. Mechanism of solubilization of immune aggregates by complement. Implications for immunopathology. Transplantation Reviews 32: 121-129.

10.- Arturo Ferreira , Victor Nussenzweig. 1976. Control of C3 levels in mice during ontogeny by a gene in the central region of the H2 complex. Nature 260: 613-615.

9.- Arturo Ferreira , Victor Nussenzweig. 1976. Influen­ce of H2 on the ontogenesis of a spleen cell population which lacks C3 receptors and Thy 1 antigen. Journal of Immunology 117: 771-773.

8.- Arturo Ferreira , Victor Nussenzweig. 1975. Genetic control of C3 levels in mice. Journal of Immunology 116: 1732

7.- Captulo de Libro : Arturo Ferreira , Victor Nussenzweig. 1975. Control of complement (C) levels by the major histo­compatibility complex (MHC). In : International Symposium on Membrane Receptors on Lymphocytes. Ed., M. Seligman. North-Ho�lland Publ . Co., Amsterdam , 1975. pp 133-139.

6.- Arturo Ferreira , Victor Nussenzweig. 1975. Genetic linkage between gene(s) controlling the serum levels of the third component of complement and the H2 complex. Journal of Experimental Medicine 141: 513-517  

5.- Arturo Ferreira , Carlos Moreno, Gustavo Hoecker. 1973. Lack of correlation between the effects of cortisone on mouse spleen plaque forming cells and circulating anti-sheep red blood cell hemolysins. Immunology 24: 607-616.

4.- Alicia Ramos, Juan Chacon, Arturo Ferreira , Gustavo Hoecker. 1973. Effects of cortisone on H2 agglutinin response in normal and thymectomized mice. Immunolog y 24: 593-599 .

3.- Capitulo de Libro: Gustavo Hoecker, Alicia Ramos, Arturo Ferreira . 1970. Restrictions of antibody production against the H2 complex. In : Cell Surface Antigens: Studies in Mammals Other Than Man. Ed., M.S.S. Informa­tion Corp . 1973. pp 167-173.

2.- Alicia Ramos, Juan Chacon, Arturo Ferreira . 1970. Thymectomy in the adult mice. Transplantation 12: 329-330.

1.- Gustavo Hoecker, Alicia Ramos, Arturo Ferreira . 1970. Restrictions of antibody production against the H2 antigenic complex. Transplantation Proceedings 2: 76-82.

 

 

Marcela A. Hermoso Ramello

Doctora en Ciencias Biológicas

Profesor Asistente

Línea de Investigación

Inmunidad Innata

mhermoso@med.uchile.cl

 

18. Sofía E. Sepúlveda, Caroll J. Beltrán, Alexis Peralta, Paola Rivas, Néstor Rojas, Carolina Figueroa, Rodrigo Quera, Marcela A. Hermoso. Enfermedad Inflamatoria Intestinal: Una mirada inmunológica. [Inflammatory Bowel Disease: An immunological view]. Rev Med Chile 2007 (In press).

17. Mariana Ríos, Marcela Hermoso, Trinidad M. Sánchez, Horacio B. Croxatto and Manuel J. Villalón. Effect of oestradiol and progesterone on instant and directional velocity of microsphere movements in the rat oviduct: gap junctions mediate kinetic effect of oestradiol. Reprod Fertil Develop 2007 (Accepted)

16. Caroll Beltrán, Frano Malinarich, Alejandra Manzanares, Sofía Sepúlveda, Marcela A. Hermoso. Inmunidad Innata en la Mucosa Intestinal. Gastr Latinoam. 2007 (In press).

15. S. Pérez Martínez, M. Hermoso, M. Farina, M.L. Ribeiro, M. Rapanelli, M. Espinosa, M. Villalón, A. Franchi. 17-Β- Estradiol Upregulates Cox-2 In The Rat Oviduct. (2006) Prostaglandins and other Lipids Mediators, 80 (3-4):155-164.

14. Sergio A. Arancibia, Caroll J. Beltran, Isabel M. Aguirre, Paulina Silva, Alexis L. Peralta, Frano Malinarich and Marcela A. Hermoso (*). Toll-like Receptors are Key Participants in Innate Immune Responses. Biol Research 2007, (In press)

13.Iruretagoyena MI, Sepulveda SE, Lezana JP, Hermoso M, Bronfman M, Gutierrez MA, Jacobelli SH, Kalergis AM. Inhibition of NF-kB enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in Experimental Autoimmune Encephalomyelitis. J. Pharmacolol Exp Ther 2006, 318(1):59-67.

12. Figueroa C, Peralta A, Herrera L, Castro P, Gutierrez A, Aguillón  JC,  Quera R, Valenzuela J, Hermoso MA (*). NOD2/CARD15 and Toll-like 4 receptor gene polymorphism in a group of Chilean patients with Inflammatory Bowel Disease. (2006) European Cytokine Network 17 (2):125-30.

11. Sepúlveda SE, Beltrán C, Rivas P, Rojas N, Figueroa C, Quera R, Hermoso MA (*). Enfermedad Inflamatoria Intestinal: Una mirada inmunológica. Rev Med Chile 2007 (Accepted).

10.  Caroll Beltrán, Julia Guerrero, Pedro Castro, Alexis Peralta, Carolina Figueroa, Rodrigo Quera, Jorge Valenzuela, Marcela A. Hermoso (*). Papel del Sistema Inmune en el Desarrollo de las Enfermedades Inflamatorias Intestinales. (2005) Gastr Latinoam 16 (3):208-221.

9.  Marcela A. Hermoso, Tetsuya Matsuguchi and John A. Cidlowski. Synergistic Regulation of the Toll-Like Receptor 2 by Tumor Necrosis Factor a and Dexamethasone. (2004)  Molecular Cell Biology 24 (11):4743-4756.

8. Marcela Hermoso, Pablo Olivero, Rubén Torres, Ana Riveros, Andrew F. G. Quest, Andrés Stutzin. Cell Volume Regulation in Response to Hypotonicity Is Impaired in HeLa Cells Expressing a Protein Kinase Ca Mutant Lacking Kinase Activity. (2004) Journal of Biological Chemistry 279 (17): 17681-17689.

7. Marcela A. Hermoso and John A. Cidlowski. Putting the Brake in Inflammatory Responses: the Role of Glucocorticoids. (2003) IUBMB Life 55(9):497-504.

6. Marcela Hermoso, Christina M. Satterwhite, Yaniré Naty Andrade, Jorge Hidalgo, Sean M. Wilson, Burton Horowitz, and Joseph R. Hume. ClC-3 is a fundamental molecular component of volume-sensitive outwardly rectifying Cl- channels and volume regulation in HeLa cells and Xenopus laevis oocytes. (2002) Journal of Biological Chemistry 277: 40066-40074.

5. Duan D, Zhong J, Hermoso M, Satterwhite CM, Rossow CF, Hatton WJ, Yamboliev I, Horowitz B, Hume JR. Functional inhibition of native volume-sensitive outwardly rectifying anion channels in muscle cells and Xenopus oocytes by anti-ClC-3 antibody. (2001) The Journal of Physiology 531.2, pp. 437-444.

4. Hermoso M, Barrera N, Morales B, Pérez S, Villalón M. (2001) Platelet Activating Factor increases ciliary activity in hamster oviduct through epithelial production of Prostaglandin E2. Pflügers Archives European Journal of Physiology 442(3):336-45.

3. Hermoso M, JC. Sáez, MJ Villalón: Identification of Gap Junctions in epithelial cells of the oviduct and regulation of connexins during development and by sexual hormones. (1997) European Journal of  Cell Biology 74:1-9.

2. Croxatto HB, Ortiz, ME, Villalón M, Cárdenas H, Imarai M, Hermoso M, Velasquez L, Orihuela PC. Basic Aspects of Oviduct Function. In: C Coutifaris, L Mastroianni (eds.): New Horizons in Reproductive Medicine. Castertron, UK: Parthenon Publ Co. 1997, pp 233-239.

1. Villalón M, Hermoso M, Budinich M, Aguilera J, Saez JC. Regulation of smooth muscle activity and GAP junctions by sexual hormones in the oviduct. In: R. La Torre, J.C. Sáez (eds): From Ionic channels to cell-to-cell conversation. 1996, Plenum Press,New York, pp 459-468.

 

 

Mercedes Lopez Nitsche

Médico Cirujano

Inmunólogo Clínico

Doctor (c) en Ciencias Biomédicas

Profesora Asistente

Línea de Investigación

Regulación e Inmunología del Cáncer

melopez@med.uchile.cl

 

11. Mercedes López, Alejandro Escobar, Jorge Alfaro, Miguel Fodor, Milton Larrondo, Carlos Ferrada, Flavio Salazar-Onfray. Avances en inmunoterapia celular contra el melanoma maligno. Revista Médica de Chile. (Accepted)

10. Ariadna Mendoza-Naranjo, Pablo J. Saéz , C. Christian Johansson, Marcos Ramírez, Dinka Mandaković, Cristian Pereda, Mercedes N. López, Rolf Kiessling, Juan C. Sáez, and Flavio Salazar-Onfray. Functional GAP junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. Journal of Immunology. 2007

9. Flavio Salazar-Onfray, Mercedes N. López  and Ariadna Mendoza-Naranjo. Paradoxical effects of cytokines in tumor immune surveillance and tumor-immune escape. Cytokine Growth Factor Rev. 2007 Feb-Apr;18(1-2):171-82.

8. Mercedes N. López, Cristian Pereda, Marcos Ramírez, Ariadna Mendoza-Naranjo, Antonio Serrano, Arturo Ferreira, Rodrigo Poblete, Alexis M. Kalergis, Rolf Kiessling, and Flavio Salazar-Onfray. Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new Target for diagnosis and immunotherapy. Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1219-27.

7. Mercedes López, Raquel Aguilera, Claudio Pérez, Ariadna Mendoza-Naranjo,Cristian Pereda, Marcos Ramirez, Carlos Ferrada, Juan Carlos Aguillón, Flavio Salazar-Onfray. The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines. Immunobiology 211 (2006) 127–136

6. A. Escobar, M. López, A. Serrano, M. Ramirez, C. Pérez, A. Aguirre, R. González,J. Alfaro,M. Larrondo, M. Fodor, C. Ferrada and F. Salazar-Onfray* Dendritic cell immunizations alone or combined with low doses of interleukin-2 induce specific immune responses in melanoma patients. Clinical and Experimental Immunology (2005) 142:555–568

5. Mercedes López, Alejandro Escobar, Jorge Alfaro, Miguel Fodor, Milton Larrondo, Carlos Ferrada, Flavio Salazar-Onfray. Avances en inmunoterapia celular contra el melanoma maligno. Rev Méd Chile 2004; 132: 1115-1126

4. Juan Carlos Aguillón, Juan Contreras, Andrés Dotte, Andrea Cruzat, Diego Catalán, Lorena Salazar, María Carmen Molina, Julia Guerrero, Mercedes López, Lilian Soto, Flavio Salazar-Onfray y Miguel Cuchacovich. Revista Médica de Chile (2003). Vol 131: 1445-1453

3. Mónica Kurte, Mercedes López, Juan Carlos Aguillón, Max Petersson, Jehad Charo, Rolf Kiessling and Flavio Salazar Onfray. A synthetic peptide homologous to the functional domain of human interleukin 10 downregulates the expression of the MHC class I alpha chain and TAP1/2 in human melanoma cells. Journal of Immunology. (2004): 173:1731-1738

2. Flavio Salazar-Onfray, Mercedes López, Andreas Lundqvist, Adam Aguirre, Antonio Serrano, Carola Korenblit, Takako Nafumiyo, Max Petersson, Viyaj Chhajlani, Olle Larsson and Rolf Kiessling. Expression of Melanocortin 1 receptor (MC1R) in melanomas and normal tissues. British Journal of  Cancer.(2002).87(4):414-22.

1.Carlos Ferrada, Flavio Salazar, Mercedes López y Alejandro Escobar. Protocolo de tratamiento melanoma avanzado con células dendríticas. Estudio fase I de inmunización de pacientes con melanoma avanzado, con células dendríticas pulsadas con extractos tumorales. Revista Chilena de Cancerología y Hematología. (2001). Vol 11. 9-20

 

 

María Carmen Molina Sampayo

Químico Farmacéutico

Doctor en Ciencias Biomédicas

Profesor Asistente

Línea de Investigación

Inmunovigilancia y Evasión Inmune

mcmolina@med.uchile.cl

 

13. Lladser A, Parraga M, Quevedo L, Carmen Molina M, Silva S, Ferreira A, Billetta R, G Quest AF. Naked DNA immunization as an approach to target the generic tumor antigen survivin induces humoral and cellular immune responses in mice. Immunobiology. 211:11-27. 2006.

12. Aguilar L, Ramirez G, Valck C, Molina MC, Rojas A, Schwaeble W, Ferreira V, Ferreira A. F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first component of human complement .Biological research. 38:187-95. 2005.

11. Ferreira V, Molina MC, Schwaeble W, Lemus D, Ferreira A. Does Trypanosoma Cruzi Calreticulin Modulate The Complement System And Angiogenesis?. Trends Parasitol. 21:169-74. 2005.

10. Molina MC, Ferreira V, Valck C, Aguilar L, Orellana J, Rojas A, Ramirez G, Billetta R, Schwaeble W, Lemus D, Ferreira A. An In Vivo Role For Trypanosoma Cruzi Calreticulin In Antiangiogenesis. Mol Biochem Parasitol. 140:133-40. 2005.

9. Ferreira V, Valck C, Sanchez G, Gingras A, Tzima S, Molina MC, Sim R, Schwaeble W, Ferreira A. The Classical Activation Pathway Of The Human Complement System Is Specifically Inhibited By Calreticulin From Trypanosoma Cruzi. J Immunol. 172:3042-50. 2004.

8. Molina MC, Cruzat L, Canals M, Cattán P, Aguillón JC, Ferreira A. Development of Immunometric Assays to Asses the Alimentary Behavior of Mepraia spinolai. Parasitol Res. 92: 375-379. 2004.

7. Ferreira V, Molina MC, Valck C, Rojas A, Aguilar L, Ramirez G, Schwaeble W, Ferreira A. Role Of Calreticulin From Parasites In Its Interaction With Vertebrate Hosts.  Mol Immunol. 40:1279-91. 2004.

6. Aguillon JC, Contreras J, Dotte A, Cruzat A, Catalan D, Salazar L, Molina MC, Guerrero J, Lopez M, Soto L, Salazar-Onfray F, Cuchacovich M. “Nuevas armas inmunológicas para la medicina del Siglo XXI: Terapia biológica basada en el uso de anticuerpos monoclonales de última generación”. Revista Médica de Chile. 131:1445-53. 2003

5. Aguirre A, Escobar A, Ferreira V, Molina MC, Ferreira A, Aguillon JC. An Anti-Human Recombinant Tumor Necrosis Factor Alpha (TNF Alpha) Monoclonal Antibody Recognizes An Epitope In Feline TNF Alpha. Vet Res. 34:177-84. 2003.

4. Araya V, Aguirre A, Romero C, Molina MC, Miranda C, Ferreira A. In vitro TNF Alpha Producing Capacity of Lipopolysaccharide Stimulated Monocytes from Women with Polycystic Ovary Syndrome. Eur Cytokyne Netw. 13:1-6. 2002

3. Ferreira V, Molina MC, Valck C, Rojas A, Ferreira A. Parasite Calreticulin: Possible Roles in the Parasite/Host Interface. Inmunología (Madrid). 21:156-168. 2002.

2. Canals M, Cruzat L, Molina MC, Ferreira A, Cattan PE. Blood Host Sources Of Mepraia Spinolai (Heteroptera: Reduviidae), Wild Vector Of Chagas Disease In Chile. J Med Entomol. 38:303-7. 2001.

1. Aguillon JC, Escobar A, Ferreira V, Aguirre A, Ferreira L, Molina MC, Ferreira A. Daily Production Of Human Tumor Necrosis Factor In Lipopolysaccharide (LPS)-Stimulated Ex Vivo Blood Culture Assays. Eur Cytokine Netw. 12:105-10. 2001.

 

 

Flavio Salazar Onfray

Biólogo

Doctor en Inmunología

Profesor Asociado

Línea de Investigación

Inmunología Antitumoral

fsalazar@med.uchile.cl

 

24. Ariadna Mendoza-Naranjo, Pablo J. Saez , C. Christian Johansson, Marcos Ramirez, Dinka Mandakovic, Cristian Pereda, Mercedes N. Lopez, Rolf Kiessling, Juan C. Saez, and Flavio Salazar-Onfray. Functional GAP junctions facilitate melanoma antigen transfer and cross-presentation between human dendritic cells. Journal of Immunology. 2007

23. Salazar-Onfray F , Lopez MN, Mendoza-Naranjo A. (2007) Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Factor Rev. Feb 26

22. Lopez MN, Pereda C, Ramirez M, Mendoza-Naranjo A, Serrano A, Ferreira A, Poblete R, Kalergis AM, Kiessling R, Salazar-Onfray F . (2007) Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy. Invest Ophthalmol Vis Sci. Mar;48(3):1219-27.

21. Cuchacovich M, Soto L, Edwardes M, Gutierrez M, Llanos C, Pacheco D, Sabugo F, Alamo M, Fuentealba C, Villanueva L, Gatica H, Schiattino I, Salazaro L, Catalan D, Valenzuela O, Salazar-Onfray F , Aguillon JC. (2006). Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis. Scand J Rheumatol. Nov-Dec;35(6):435-40.

20. Lopez M, Aguilera R, Perez C, Mendoza-Naranjo A, Pereda C, Ramirez M, Ferrada C, Aguillon JC, Salazar-Onfray F . (2006) The role of regulatory T lymphocytes in the induced immune response mediated by biological vaccines. Immunobiology. 211(1-2):127-36.

19. Gomez CR, Acuna-Castillo C, Nishimura S, Perez V, Escobar A, Salazar-Onfray F , Sabaj V, Torres C, Walter R, Sierra F. (2006) Serum from aged F344 rats conditions the activation of young macrophages. Mech Ageing Dev . Mar;127(3):257-63.

18. Escobar A, Lopez M, Serrano A, Ramirez M, Perez C, Aguirre A, Gonzalez R, Alfaro J, Larrondo M, Fodor M, Ferrada C, Salazar-Onfray F .(2005) Dendritic cell immunizations alone or combined with low doses of interleukin-2 induce specific immune responses in melanoma patients. Clin Exp Immunol. Dec;142(3):555-68.

17. Lopez M, Escobar A, Alfaro J, Fodor M, Larrondo M, Ferrada C, Salazar-Onfray F. (2004) Advances in cellular immunotherapy for malignant melanoma Rev Med Chil. Sep;132(9):1115-26.

16. Kurte M, Lopez M, Aguirre A, Escobar A, Aguillon JC, Charo J, Larsen CG, Kiessling R, Salazar-Onfray F . (2004) A synthetic peptide homologous to functional domain of human IL-10 down-regulates expression of MHC class I and Transporter associated with Antigen Processing 1/2 in human melanoma cells. J Immunol. Aug 1;173(3):1731-7.

15. Cuchacovich M, Ferreira L, Aliste M, Soto L, Cuenca J, Cruzat A, Gatica H, Schiattino I, Perez C, Aguirre A, Salazar-Onfray F , Aguillon JC. (2004) Tumour necrosis factor-alpha (TNF-alpha) levels and influence of -308 TNF-alpha promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis. Scand J Rheumatol. 33(4):228-32.

14. Aguillon JC, Contreras J, Dotte A, Cruzat A, Catalan D, Salazar L, Molina MC, Guerrero J, Lopez M, Soto L, Salazar-Onfray F , Cuchacovich M. (2003) New immunological weapons for medicine in the 21st Century: biological therapy based on the use of the latest generation monoclonal antibodies Rev Med Chil. Dec 131(12):1445-53.

13. Cuenca J, Cuchacovich M, Perez C, Ferreira L, Aguirre A, Schiattino I, Soto L, Cruzat A, Salazar-Onfray F , Aguillon JC. (2003) The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis. Rheumatology . Feb 42(2):308-13.

12 . Salazar-Onfray F , Lopez M, Lundqvist A, Aguirre A, Escobar A, Serrano A, Korenblit C, Petersson M, Chhajlani V, Larsson O, Kiessling R. (2002) Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker. Br J Cancer. Aug 12;87(4):414-22.

11. Ferrada C., Salazar F ., Lopez M., Escobar A., (2001). Protocolo de tratamiento de melanoma avanzado con clulas dendrticas. Estudio de fase II de inmunizacin de pacientes con melanoma avanzada con extractos tumorales. Rev. Chi. Cancerologa y Hematologa . Vol 11. 9-20

10. Salazar-Onfray. (2000). El Sistema Inmune, herramienta estrategica en la batalla contra el cancer. Rev. Chi. Ped . Vol 71

9. Rongcun Y, Salazar-Onfray F , Charo J, Malmberg KJ, Evrin K, Maes H, Kono K, Hising C, Petersson M, Larsson O, Lan L, Appella E, Sette A, Celis E, Kiessling R. (1999) Identification of new HER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas. J Immunol Jul 15;163(2):1037-44.

8. Salazar-Onfray F . (1999) Interleukin-10: a cytokine used by tumors to escape immunosurveillance. Med Oncol. Jul;16(2):86-94. Review.

7. Petersson M, Charo J, Salazar-Onfray F , Noffz G, Mohaupt M, Qin Z, Klein G, Blankenstein T, Kiessling R. (1998) Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP)-1/2 function in the prototype NK target YAC-1. J I mmunol. Sep 1;161(5):2099-105.

6. Salazar-Onfray F , Nakazawa T, Chhajlani V, Petersson M, Karre K, Masucci G, Celis E, Sette A, Southwood S, Appella E, Kiessling R . (1997) Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells. Cancer Res. Oct 1;57(19):4348-55.

5. Salazar-Onfray F , Charo J, Petersson M, Freland S, Noffz G, Qin Z, Blankenstein T, Ljunggren HG, Kiessling R. (1997) Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10. J Immunol. Oct 1;159(7):3195-202.

4. Masucci G, Svensson A, Hansson M, Hansson J, Nakazawa T, Salazar F , Petersson M, Kiessling R. (1997) Efficient harvest of in vivo IL-2-activated CD3+ lymphocytes for adoptive immunotherapy by selective leukapheresis (lymphocytapheresis). J Hematother. Jun;6(3):253-60.

3. Kono K, Salazar-Onfray F , Petersson M, Hansson J, Masucci G, Wasserman K, Nakazawa T, Anderson P, Kiessling R. (1996) Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity. Eur J Immunol. Jun;26(6):1308-13.

2. Salazar-Onfray F , Petersson M, Franksson L, Matsuda M, Blankenstein T, Karre K, Kiessling R. (1995) IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression. J Immunol. Jun 15;154(12):6291-8.

1. Matsuda M, Salazar F , Petersson M, Masucci G, Hansson J, Pisa P, Zhang QJ, Masucci MG, Kiessling R. (1994) Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression. J Exp Med. 1994 Dec 1;180(6):2371-6.

Copyright © 2007 Inmunito el al. Todos los derechos reservados.